The end of times will come because of the black plague

The black plague spreading across Europe was interpreted by many as the sign of the end of times.

Boyett, Jason (2005). Pocket Guide to the Apocalypse: The Official Field Manual for the End of the World. Relevant Media Group; Byrne, Joseph Patrick (2008). Encyclopedia of Pestilence, Pandemics, and Plagues, Volume 1. Greenwood Publishing Group. p. 67