An uncontrollable epidemic will kill most people on the planet

Jack London : writer
People will die during a day. One of a million will survive. The whole civilization will disappear in a few days.
The Scarlet Death is quite similar to Ebola, a virus with a death rate of 90% and the same symptoms. There is no antidote for it.

London, J., (1912) The Scarlet Plague, London, London Magazine