Organic human beings will be a small minority of the intelligent life forms on Earth. Even among the remaining Homo sapiens, the use of computerized implants that heavily augment normal abilities will be ubiquitous and accepted as normal. The small fraction of humans who opt to remain "natural" and unmodified effectively will exist on a lower and more limited plane of consciousness from everyone else, and thus find it impossible to fully interact with AI's and highly modified humans. In spite of their shortcomings and frailties, humans are respected by AI's for giving rise to the machines.
Kurzweil, Ray. 1999. The age of spiritual machines: when computers exceed human intelligence. New York: Viking.